In 1962, Perignem set up his own ceramics and glassware business, where he began designing glass pieces that soon attracted the attention of the design world. His creations were characterized by organic shapes and bold, vivid colors, which were both elegant and functional.
Over the years, Perignem has worked with many renowned companies, including Val Saint-Lambert, Baccarat and Rosenthal. He also received numerous awards for his designs, including the Grand Prix de la Triennale de Milan in 1964 and the Prix Henry van de Velde in 1974.
Today, Hugues Perignem's creations are considered icons of Belgian design and are exhibited in numerous museums and art galleries around the world.