In 1968, Gramigna founded his own design studio in Milan, focusing primarily on furniture, lighting and home accessories. Her designs are characterized by elegant simplicity and great attention to detail.
Over the course of her career, Gramigna has worked with leading Italian brands such as Artemide, Zanotta and Poltrona Frau. She has also won several prestigious awards for her design work, including the Compasso d'Oro in 1970 and 1981.
Today, Gramigna is considered one of the most influential Italian designers of her generation, having helped shape the aesthetics of contemporary Italian design.