Michelucci studied architecture at Florence's Polytechnic, graduating in 1921. He began his career working as an architect in the office of the architect Giovanni Muzio in Milan. He subsequently worked as professor of architecture at the University of Florence for several years.
One of Michelucci's most famous projects is the Santa Maria Novella railway station in Florence, built between 1932 and 1935. This building is considered an outstanding example of Italian rationalist architecture, combining modern elements with references to the architectural traditions of the region.
Michelucci also designed many other buildings, including churches, museums, universities and residential complexes. He was known for his innovative approach and his ability to integrate architecture harmoniously with its natural surroundings.
In addition to his work as an architect, Michelucci also created industrial designs. He designed furniture, lighting and functional objects, seeking to combine aesthetics and functionality in his creations.
Throughout his career, Michelucci received numerous awards for his work, including the Médaille d'or prize from the Académie d'architecture de Paris in 1961. His influence on Italian and international architecture endures, and his work continues to be studied and appreciated by many architects and designers.