Branzi began his career as an architect in the 60s, but soon turned to industrial design, working for companies such as Alessi, Artemide and Zanotta. He also co-founded the design group Archizoom Associati in 1966, which pioneered the radical movement of the late 60s in Italy.
In the 80s, Branzi began to focus on design theory and research, and was appointed professor at Milan Polytechnic. He also co-founded the Domus Academy design group in Milan, which has become one of the world's most prestigious design establishments.
Branzi's creations are often characterized by their poetic aspect and sense of irony, as well as their use of innovative materials and organic forms. His work has been exhibited in numerous museums and galleries around the world, and he has won many prestigious awards for his work, including the Compasso d'Oro in 1987 and 1995.
Branzi continues to work and teach today, and his contributions have profoundly influenced Italian and international design.